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Case series: Using NATROX® Oxygen Wound Therapy in the management of diabetic foot ulcers

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Case series: Using NATROX® Oxygen Wound Therapy in the management of diabetic foot ulcers

Supported by Inotec AMD
Debbie Wilson, Diane Knowles, Elaine Ricci, Kaye McIntyre, Keith Harding, Keri Hutchinson, Leah Litchfield, Paul Goodfellow
1 November 2019

Diabetic foot ulcers (DFUs) are complex wounds with a complicated aetiology. Diabetic foot ulceration is a marker of serious complications and comorbidities of diabetes. DFUs have a major long-term health impact on patients’ morbidity and mortality (Jupiter et al, 2016), and also represent a significant impact on patient quality of life. Many patients with DFUs report pain levels that affect daily activities and disrupt sleep (Bradbury and Price, 2011).

DFUs are often ischaemic in nature, and lack of oxygen (hypoxia) can delay healing and increase the risk of complications. Hypoxia may be corrected by early intervention with topical oxygen therapy. Topical oxygen has been proven to have positive effects on chronic, hard-to-heal wounds (Harding, 2016). 

​This document contains a series of case reports describing the use of NATROX® Oxygen Wound Therapy (Inotec AMD) in patients with DFUs, alongside local protocol and guidelines.

Disclaimer: The views expressed are those of the authors and do not necessarily reflect those of Inotec AMD.
References

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Bradbury S, Price P (2011) The impact of diabetic foot ulcer pain on patient quality of life. Wounds UK 7(4): 32–49

Guest JF, Ayoub N, McIlwraith T et al (2015) Health economic burden that wounds impose on the National Health Service in the UK. BMJ Open 5: e009283

Guest JF, Fuller GW, Vowden P (2018) Diabetic foot ulcer management in clinical practice in the UK: costs and outcomes. Int Wound J 15: 43–52

Harding K (2016) The essential role of oxygen in wound healing. Presentation. Wounds UK, Harrogate. Inotec AMD Ltd. Data on file

Hayes P, Lee H, Curran G, Loftus I (2015) Topical oxygen therapy helps healing of diabetic foot ulcers. Poster presentation. Canadian Association of Wound Care (CAWC) Conference, Toronto

Ince P, Abbas ZG, Lutale JK et al (2008) Use of the SINBAD classification system and score in comparing outcome of foot ulcer management on three continents. Diabetes Care 31(5): 964–7

Jupiter DC, Thorud JC, Buckley CJ, Shibuya N (2016) The impact of foot ulceration and amputation on mortality in diabetic patients. I: From ulceration to death, a systematic review. Int Wound J 13: 892–903

Kaufman H (2016) A new approach in oxygen wound therapy: an overview of NATROX experience in Israel. Abstract and presentation. World Union of Wound Healing Societies, Florence

Kerr M (2017) Diabetic Foot Care in England: an economic study. London: Insight Health Economics for Diabetes UK

National Diabetes Footcare Audit (2017) Diabetes Foot Care: Are services in England and Wales putting your feet first? Available at: https://bit.ly/2IPGyDz (accessed 11.10.2019)

NICE (2015) Diabetic foot problems: prevention and management (NG19). London: NICE. Available at: https://www.nice.org.uk/guidance/ng19 (accessed 29.04.19)

World Health Organisation (2016) Global Report on Diabetes. WHO, Geneva, Switzerland. Available at: https://bit.ly/2HQbtiF (accessed 03.06.19)

Wounds UK (2018) Best practice recommendations for the implementation of a DFU pathway. Available at: https://bit.ly/2owsFDl (accessed 11.10.2019)

Wu S, Driver VR, Wrobel JS et al (2007) Foot ulcers in the diabetic patient, prevention and treatment. Vasc Health Risk Manag 3(1): 65–76

Yu J, Lu S, McLaren A-M et al (2016) Topical oxygen therapy results in complete wound healing in diabetic foot ulcers. J Vasc Surg 24(6): 1536

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