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BMA News |
Healthy living in middle age can help ward off dementia
BMJ Clinical Evidence: Could early intervention be the key in preventing dementia?
Having a healthy lifestyle in middle age is likely to help stave off dementia in later life, say two senior doctors in an editorial in BMJ Clinical Evidence.
A recent report by the Alzheimer's Research Trust estimated that dementia currently costs the UK economy £23 billion per year, much more than previously thought, and this is set to increase.
But evidence suggests that tackling risk factors such as obesity and high cholesterol in middle age could cut an individual's risk of developing dementia by about 20%, say Dr Tom Russ and Professor John Starr, experts in health and ageing at the University of Edinburgh.
The most important areas to address are increasing levels of exercise across all age groups, and keeping obesity, blood pressure, and cholesterol levels under control in middle age.
These measures will also have positive effects on heart disease, diabetes, and stroke.
Modifying these risk factors early enough in life to have an effect is everybody's business, they write. Primary and secondary healthcare professionals, health promotion bodies, the voluntary sector and even employers will have to play a part for a national reduction in dementia incidence to occur.
An alternative to rolling out these prevention initiatives population-wide is to specifically target people at high risk of dementia, they explain. However, they warn that there remains no preventative strategy proven to reduce the risk of developing dementia or to slow progression.
Dementia will continue to be a condition that demands attention and resources in the coming years but, with adequate funding and urgent health promotion and preventative endeavours, it can be hoped that care-providers will not be taxed beyond their limits, they conclude.
Contact:
Dr Tom Russ, Alzheimer Scotland Clinical Research Fellow, Department of Geriatric Medicine, Royal Infirmary of Edinburgh, Edinburgh, Scotland
Tel (via Emma Dickinson, BMJ Press Office): +44 (0)20 7383 6529
Email: tom.russ@nhs.net
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GUT
Indian spice may delay liver damage and cirrhosis
[Curcumin improves sclerosing cholangitis in Mdr2 -/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation Gut 2010; 59: 521-30]
Curcumin, one of the principal components of the Indian spice turmeric, seems to delay the liver damage that eventually causes cirrhosis, suggests preliminary experimental research in the journal Gut.
Curcumin, which gives turmeric its bright yellow pigment, has long been used in Indian Ayurvedic medicine to treat a wide range of gastrointestinal disorders.
Previous research has indicated that it has anti-inflammatory and antioxidant properties which may be helpful in combating disease.
The research team wanted to find out if curcumin could delay the damage caused by progressive inflammatory conditions of the liver, including primary sclerosing cholangitis and primary biliary cirrhosis.
Both of these conditions, which can be sparked by genetic faults or autoimmune disease, cause the liver's plumbing system of bile ducts to become inflamed, scarred, and blocked. This leads to extensive tissue damage and irreversible and ultimately fatal liver cirrhosis.
The research team analysed tissue and blood samples from mice with chronic liver inflammation before and after adding curcumin to their diet for a period of four and a period of eight weeks.
The results were compared with the equivalent samples from mice with the same condition, but not fed curcumin.
The findings showed that the curcumin diet significantly reduced bile duct blockage and curbed liver cell (hepatocyte) damage and scarring (fibrosis) by interfering with several chemical signalling pathways involved in the inflammatory process.
These effects were clear at both four and eight weeks. No such effects were seen in mice fed a normal diet.
The authors point out that current treatment for inflammatory liver disease involves ursodeoxycholic acid, the long term effects of which remain unclear. The other alternative is a liver transplant.
Curcumin is a natural product, they say, which seems to target several different parts of the inflammatory process, and as such, may therefore offer a very promising treatment in the future.
Contact:
Professor Michael Trauner, Laboratory of Experimental and Molecular Hepatology, Department of Internal Medicine, Medical University, Graz, Austria.
Tel (mobile): +43 664 421 594
Email: Michael.trauner@meduni-graz.at
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Forthcoming Events |
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Pisa International Diabetic Foot Courses
4 day theoretical course and practical training 4-7 October 2010
Registration open
CLICK HERE FOR INFORMATION ON FEES AND ONLINE REGISTRATION
Low registration fee - deadline 30 June 2010
The course offers:
A thorough introduction to all aspects of the diagnosis, management and treatment of the diabetic foot, based on international consensus
Practical training sessions in the diabetic foot clinic
Access to follow up support for diabetic foot clinic establishment
The course programme, faculty list and general information is available at www.diabeticfootcourses.org
If you have any further questions about the courses you are very welcome to contact the course secretariat.
Kind regards,
Prof. Alberto Piaggesi
Director of the Diabetic Foot Section of the Pisa University Hospital, University of Pisa
Course secretariat:
Pisa International Diabetic Foot Courses
C/o Congress Consultants
Martensens Allé 8
DK-1828 Frederiksberg C
Denmark
Tel: +45 70 20 03 05
Fax: +45 70 20 03 15
Mail: info@diabeticfootcourses.org
Web: www.diabeticfootcourses.org
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References |
Boone, D.; Braitman, E.; Gentics, C.; Afthinos, J.; Latif, J.; Sordillo, E.; Todd, G.; Lantis, J.C.(2010) Bacterial Burden and Wound Outcomes as Influenced by Negative Pressure Wound Therapy. WOUNDS VOL 22; NUMB 2; pp. 32-37
Kamer, E.; Unalp, H.R.; Gundogan, O.; Diniz, G.; Ortac, R.; Olukman, M.; Derici, H.; Onal, M.A. (2010) Effect of Ascorbic Acid on Incisional Wound Healing in Streptozotocin-Induced Diabetic Rats. WOUNDS VOL 22; NUMB 2; pp. 27-31
van Ramshorst, G.H.; Vrijland, W.; van der Harst, E.; Hop, W.C.J.; Hartog, D.d.; Lange, J.F. (2010) Validity of Diagnosis of Superficial Infection of Laparotomy Wounds Using Digital Photography: Inter- and Intra-observer Agreement Among Surgeons. WOUNDS VOL 22; NUMB 2; pp. 38-43
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