Made EasyCollagen dressings Made Easy

Collagen dressings Made Easy

Complex wounds, Products, Surgical wounds | Westgate S, Cutting KF, DeLuca G, Asaad K

EVIDENCE FOR type  I PISCEAN collagen dressings
The use of collagen dressings is supported by relatively sparse data, with much of the evidence derived from non-comparative case reports and clinical experience.

Piscean collagen has been used successfully to treat canine wounds, resulting in normal cell proliferation after treatment (Takai et al, 1997). In a study using a comparable bovine type I collagen matrix dressing faster healing rates were reported in 15 patients with postoperative wounds when compared to conventional treatment (6.1 vs 9.4 weeks for controls) (Kolenik et al 1999).

Anecdotal evidence to date using type 1 piscean collagen products has demonstrated that they are a useful adjunct to facilitate healing in patients with chronic ulcers (including diabetic foot and pressure ulcers), dehisced surgical wounds and donor site wounds (Medira Ltd, data on file). In addition, faster healing rates have been observed in patients with epidermolysis bullosa when using Helisorb® Particles as a primary contact layer. The product was easy to apply and impacted minimally on the patients' normal dressing regimen (DeLuca, clinical data).
Cost benefits of using collagen dressings
The potential advantages of advanced wound care products have been summarised by Vowden (2011). These include the potential to improve healing rates, reduce symptoms and improve quality of life together with a reduction in healthcare costs. Advanced therapies may add to the initial cost burden of care. It is therefore important that they are used judiciously following accurate assessment in order to avoid inappropriate application or use in inappropriate circumstances.

This made easy supplement provides a focus on collagen dressings derived from type I piscean collagen. Fish-derived collagen products are able to deliver a wide range of benefits to the wound healing process. When applied topically, the collagen acts as a haemostat and helps to stimulate the growth of new tissue in the wound bed. Piscean collagen appears to have a number of advantages over mammalian derived collagen, including decreased cost and fewer adverse immunological reactions. This advanced wound care intervention has the potential to improve healing rates, reduce symptoms and improve quality of life while reducing long-term healthcare costs.

Westgate S[1], Cutting KF[2], DeLuca G[3], Asaad K[4]
1.    Project Manager and Research Scientist, Perfectus Medical, UK
2.     Director, Perfectus Medical, UK
3.    Clinical Nurse Specialist, Plastic Surgery, St Thomas' Hospital, London
4.    Clinical Fellow, Plastic Surgery, St Thomas' Hospital, London


  • Basha SK, Kumar RVS, Haragopal V et al (2011). Effects of fish scales extracted collagen biocastings oncutaneous wound healing in dogs. Res J Pharma Biol Chem Sci 2: 36-49.
  • Boateng JS, Matthews KR, Stephens HNE (2007). Wound healing dressings and drug delivery systems: A review. J Pharm Sci 97(8): 2892-923.
  • Bradley M, Cullum N, Nelson EA, et al (1999). Systematic reviews of wound care management: (2). Dressings and topical agents used in the healing of chronic wounds. Health Technol Assess 3: 1-35.
  • Brett D (2008). A review of collagen and collagen based wound dressings. Wounds 20(12): 347-53.
  • Burns NK, Jaffari MV, Rios CN, et al (2010). Non cross-linked porcine acellular dermal matrices for abdominal wall reconstruction. Plast Reconstr Surg 125: 167-76.
  • Enoch S, Harding K (2003). Wound bed preparation: the science behind the removal of barriers to healing. Wounds 15: 213-29.
  • Gibson D, B Cullen, R Legerstee, Harding KG and Schultz G. MMPs Made Easy. Wounds International 2009; 1(1). Available from:
  • International Consensus. Acellular matrices for the treatment of wounds. Wounds International 2011. Available from
  • Jabar NA (2011). Extraction of collagen from fish waste and determination of its physico-chemical characteristics Bachelor of Science (Hons.) Final Year Project Universiti Teknologi MARA.
  • Jeffrey J (1995). Metalloproteinases and tissue turnover. Wounds 13-22.
  • Kolenik SA, McGovern TW, Leffell DJ (1999). Use of lyophilized bovine collagen matrix in postoperative wound healing. Dermatol Sci 25: 303-07.
  • Li J, Chen J, Kirsner R (2007). Pathophysiology of acute wound healing. Clin Dermatol 25: 9-18.
  • Lui Y, Griffith M, Watsky MA, et al (2006). Properties of porcine and recombinant human collagen matrices for optically clear tissue engineering applications. Biomacromolecules 7: 1819-28.
  • Mian M, Beghe F, Mian E (1992). Collagen as a pharmacological approach in wound healing. Int J Tissue React 14(Suppl): 1-9.
  • Montesano R, Orci L, Vasselli P (1983). In vitro rapid organisation of endothelial cells into capilary-like networks is promoted by collagen matrices. J Cell Biol 97: 1648-52.
  • Moore K (2010). Cell biology of normal and impaired healing. In: Percival S, Cutting KF (eds.) Microbiology of Wounds. Boca Raton, FL: CRC Press.
  • Parks WC (1995). The production, role and regulation of matrix metalloproteinases in the healing epidermis. Wounds 7: 23-37.
  • Pati F, Dhara S, Adhikari B (2010). Fish collagen: A potential material for biomedical application. Student's Technology Symposium (TechSym), 34-8.
  • Rangaraj A, Harding K, Leaper (2011). Role of collagen in wound management. Wounds UK 7(11): 54-63.
  • Rudnick A (2006). Advances in tissue engineering and use of type 1 bovine collagen particles in wound bed preparation. J Wound Care 15: 402-04.
  • Ruszczak Z (2003). Effect of collagen matrices on dermal wound healing. Adv Drug Deliv Rev 55(12):1595-611.
  • Singh O, Gupta SS, Soni M, et al (2011). Collagen dressing versus conventional dressings inburn and chronic wounds: A retrospective study.
  • J Cutan Aesthet Surg 4: 12-6.
  • Takai M, Shimizu Y, Shimizu J, et al (1997). Wound healing composition using squid chitin and fish skin collagen. Japan patent application 669,956.
  • Vivas A, Tang JC, Kirsner RS (2011). Collagen-based tissue-engineered composites. J Wound Technol 13: 62-67.
  • Vowden, P (2011). Hard-to-heal wounds Made Easy. Wounds International. Available from:
  • Weber L, Kirsch E, Muller P, et al (1984). Collagen type distribution and macromolecular organization of connective tissue in different layers of human skin. J Inv Derm 82:156-60.
  • Zbigniew R (2003). Effect of collagen matrices on dermal wound healing. Adv Drug Del Rev 55: 1595-611.

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