Journal articlesImpact of medications and lifestyle factors on wound healing: A pilot study

Impact of medications and lifestyle factors on wound healing: A pilot study

01/03/13 | Education, Research | Charlotte Wigston, Shoaib Hassan, Suzanna Turvey, David Bosanquet, Alastair Richards, Samantha Holloway, Keith Harding

Background:Wound chronicity can be due to a range ofintrinsic and extrinsic factors, some of which can be controlled. Aim: The main aim of this pilotstudy wasto explore how medications, smoking, and alcohol affect healing rates in a sample of patients at three tertiary wound care clinics.Methods: Seventy-three patients, each with an open wound,wereincludedinthestudy.Medicalhistory,concomitantmedications,smoking status, and alcohol consumption were recorded. Patients’ wounds were classified as healing or nonhealing based on the comparisons of wound size change since previous visits. Logistic regression with groups of medications known to affect wound healing was undertaken to investigate their ability to independently predict outcome. Results: Groups were wellmatched for comorbidities, and amount of concomitantmedications taken. Logistical regression identified antibiotics as being associated with healing, although this did notreach statisticalsignificance (P=0.07). Alcohol consumption over the recommended allowance was associated with nonhealing (P=0.043). Conclusion: The results suggest that excess alcohol consumption may delay wound healing. A larger study is needed to further the questions.