Heavily exuding, infected cavity wounds requiring negative pressure wound therapy (NPWT) can become chronically inert over time, resulting in complex clinical, financial and personal challenges to healthcare workers and patients. This evaluation explored the benefits of utilising a DACC-coated antimicrobial wound contact layer in conjunction with NPWT in 10 patients with heavily exuding, infected wounds. The results demonstrated positive outcomes in regards to non-adherence, atraumatic application and removal, reduction in bacterial burden and exudate levels and timely downgrading from NPWT to conventional dressing therapies.