Aims: Flexibility and conformability are key performance characteristics in dressing design and construction, which can have an impact on product suitability in the clinical environment. This study evaluated both quantitatively and qualitatively the conformability and comfort of a variety of wound dressings (Biatain® Soft/Ag/Non-adhesive (Coloplast), Allevyn® Gentle (Smith and Nephew), Mepilex®/Mepilex® Ag, Mölnlycke Health Care) using established laboratory-based methods. These were supported by a healthy volunteer study of Mepilex Border and Allevyn Gentle Border. Results: In vitro, Mepilex was found to be more conformable and able to mould to smaller radii than the other products tested. The volunteer study supported this finding and showed that Mepilex Border dressings were more comfortable and conformable than the comparator (Allevyn Gentle Border). Statistical analysis was not possible as more than 50% of the comparator products did not remain in situ over the study period. Conclusions: Mepilex and Mepilex Border were shown to achieve higher levels of conformability and comfort in the laboratory tests and volunteer studies respectively. This is an important feature in clinical use. Conflict of interest: This manuscript was supported by an educational grant from Mölnlycke Health Care, Gothenburg, Sweden.